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Synfacts 2009(11): 1193-1193  
DOI: 10.1055/s-0029-1218031
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-7-Methylomuralide

Contributor(s): Philip Kocienski, Stewart Eccles
R. A. Shenvi, E. J. Corey*
Harvard University, Cambridge, USA
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Publication History

Publication Date:
22 October 2009 (online)

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Significance

Methylomuralide is a simpler relative of omuralide (by the addition of a methyl at C7), which is the active metabolite of the proteasome inhibitor lactacystin. This synthetic approach to methylomuralide should allow for rapid and inexpensive production of both the racemic and enantiomerically pure compound.