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Synfacts 2009(11): 1218-1218  
DOI: 10.1055/s-0029-1218088
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

High-Yielding Click Route to Macrocycles

Contributor(s): Timothy M. Swager, Jan M. Schnorr
S. Binauld, C. J. Hawker, E. Fleury, E. Drockenmuller*
Université Claude Bernard Lyon 1, France and University of California, Santa Barbara, USA
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Publication History

Publication Date:
22 October 2009 (online)

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Significance

The authors present an iterative route to crown ether based macrocycles of different sizes (16-19). The cyclization step under pseudo-high-dilution conditions proceeds in very high yields of 86-91%.