Synfacts 2009(11): 1285-1285  
DOI: 10.1055/s-0029-1218108
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Continuous-Flow Mannich Reactions Using a Solid-Supported Hydroxyproline

Contributor(s): Benjamin List, Frank Lay
E. Alza, C. Rodríguez-Escrich, S. Sayalero, A. Bastero, M. A. Pericàs*
Institute of Chemical Research of Catalonia, Tarragona and Universitat de Barcelona, Spain
Further Information

Publication History

Publication Date:
22 October 2009 (online)

Significance

The authors developed a solid-­supported hydroxyproline 1 which catalyzes the Mannich reaction of aldehydes and ketones with N-PMP-ethyl glyoxylate imine efficiently in high yields, dia­stereoselectivities, and enantioselectivities. For ­aldehydes the reaction was implemented in a flow system allowing continuous synthesis with a residence time of minutes and a fourfold reduction of catalyst with respect to the batch process.