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Synfacts 2009(11): 1278-1278
DOI: 10.1055/s-0029-1218114
DOI: 10.1055/s-0029-1218114
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Aminocatalysis Cascades of α-Branched α,β-Unsaturated Aldehydes
P. Galzerano, F. Pesciaioli, A. Mazzanti, G. Bartoli, P. Melchiorre*
Università di Bologna, Italy and Institute of Chemical Research of Catalonia, Tarragona, Spain
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Oktober 2009 (online)
Significance
A highly enantioselective aminocatalytic activation of α-substituted α,β-unsaturated aldehydes is reported. Friedel-Crafts-amination and sulfa-Michael-amination cascade reactions are catalyzed by chiral primary amine 1 through a well defined iminium ion-enamine reaction sequence.