Download PDF
Synfacts 2009(11): 1251-1251  
DOI: 10.1055/s-0029-1218133
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of γ,δ-Unsaturated Ketones from Methylenecyclopropanes

Contributor(s): Mark Lautens, Jane Panteleev
H. Taniguchi, T. Ohmura*, M. Suginome*
Kyoto University, Japan
Further Information

Publication History

Publication Date:
22 October 2009 (online)

    Permissions and Reprints

Significance

Addition of aldehydes across a variety of unsaturated substrates to yield ketones can be a valuable method for constructing complex synthons (see Review below). The authors ­report on a hydroacylation of methylenecyclopropanes (MCPs) to give γ,δ-unsaturated ketones. The method is general and affords products in ­excellent diastereoselectivity and good yields.