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Synfacts 2009(12): 1390-1390  
DOI: 10.1055/s-0029-1218169
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Nickel-Catalyzed Addition of Organo-boronates to Aldehydes and Ketones

Contributor(s): Paul Knochel, Andrei Gavryushin
J. Bouffard, K. Itami*
Nagoya University, Japan
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

A Ni(0)-NHC catalyst efficiently promotes the 1,2-addition of arylboronate esters to carbonyl compounds. This method allows obtaining a variety of benzylic alcohols, including sterically hindered ones and substituted triarylmethanols. The procedure is relatively simple, employs mild conditions, and tolerates the presence of various functional groups in the reactants.