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Synfacts 2009(12): 1366-1366  
DOI: 10.1055/s-0029-1218235
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Platinum-Catalyzed Asymmetric Diboration of Terminal Alkenes

Contributor(s): Hisashi Yamamoto, Zhi Li
L. T. Kliman, S. N. Mlynarski, J. P. Morken*
Boston College, Chestnut Hill, USA
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

After previous work on catalytic asymmetric 1,4-diboration of 1,3-dienes (J. Am. Chem. Soc. 2009, 131, 9134), enantioselective 1,2-diboration of terminal alkenes with platinum complexes was developed in the same group. Platinum chiral phosphonite ligand complexes are able to provide excellent yields and enantioselectivities for various terminal olefin substrates. The diborane products are subjected to further transformations to furnish many useful enantiomer-­enriched compounds.