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Synfacts 2009(12): 1316-1316  
DOI: 10.1055/s-0029-1218326
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Cortistatin Analogues

Contributor(s): Philip Kocienski
B. Czakó, L. Kürti, A. Mammoto, D. E. Ingber, E. J. Corey*
Harvard University, Cambridge and Harvard Medical School, Boston, USA
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

Cortistatins A and J display significant antiangiogenic activity. Several potent water soluble analogues were synthesized that may be suitable to treat ocular and macular degeneration and related angiogenesis-dependent afflictions. The analogue shown in the scheme exceeds the antiangiogenic potency of cortistatin A in vitro.