Formal Synthesis of Diazonamide A

Significance

Diazonamide A was isolated from colonial ascidian Diazona angulata in 1991. The main synthetic challenge presented by diazon­amide A is the hindered quaternary center at C10. To date, three total syntheses have been developed: one by the Nicolaou group, one by Harran and co-workers, and a formal synthesis by ­Magnus and co-workers.