Neonatal Hepatic Mesenchymal Hamartoma Causing Cardiac Failure and Disseminated Intravascular Coagulopathy

ABSTRACT

Even with advance prenatal diagnostic tools, differentiating among specific types of hepatic masses continues to challenge many physicians. Here, we report a neonate with life-threatening hepatic mass, cardiac failure, and disseminated intravascular coagulopathy, which clinically resembled hepatic hemangioma. A hepatic mesenchymal hamartoma was detected by postmortem pathology.

KEYWORDS

Neonatal hepatic mass - mesenchymal hamartoma - DIC - cardiac failure - embolization

REFERENCES

• 1 Christison-Lagay E R, Burrows P E, Alomari A et al.. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry.  J Pediatr Surg. 2007;  42 62-67
• 2 Isaacs H. Fetal and neonatal hepatic tumors.  J Pediatr Surg. 2007;  42 1797-1803
• 3 Stringer M D, Alizai N K. Mesenchymal hamartoma of the liver: a systemic review.  J Pediatr Surg. 2005;  40 1681-1690
• 4 Von Schweinitz D. Neonatal liver tumors.  Semin Neonatol. 2003;  8 403-410
• 5 Akiyoshi K, Mizote H, Tanaka Y, Nakagawa M. Capillary hemangioma of the liver with Kassabach-Merritt syndrome in a neonate: report of a case.  Surg Today. 2000;  30 86-88
• 6 Mulrooney D A, Carpenter B, Georgieff M et al.. Hepatic mesenchymal hamartoma in a neonate: a case report and review of literature.  J Pediatr Hematol Oncol. 2001;  23 316-317
• 7 Ontachi Y, Asakura H, Omote M, Yoshida T, Matsui O, Nakao S. Kasabach-Merritt syndrome associated with giant liver hemangioma: the effect of combined therapy with danaparoid sodium and tranexamic acid.  Haematologica. 2005;  90(suppl) ECR29
• 8 Rao S P, Bhagavath S, Chen C K, Tolete-Velcek F. Mesechymal hamartoma of the liver in an older child: association with disseminated intravascular coagulation.  Med Pediatr Oncol. 1984;  12 112-115
• 9 Chou S Y, Chiang H K, Chow P K, Wu C F, Liang S J, Hsu C S. Fetal hepatic hemangioma diagnosed prenatally with ultrasonography.  Acta Obstet Gynecol Scand. 2005;  84 301-302
• 10 Laberge J M, Patenaude Y, Desilets V et al.. Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise.  Fetal Diagn Ther. 2005;  20 141-145
• 11 Dickinson J E, Knowles S, Phillips J M. Prenatal diagnosis of hepatic mesenchymal hamartoma.  Prenat Diagn. 1999;  19 81-84
• 12 Carta M, Maresi E, Giuffrè M et al.. Congenital hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta: case report.  J Pediatr Surg. 2005;  40 E37-E39
• 13 Yen J B, Kong M S, Lin J N. Hepatic mesenchymal hamartoma.  J Paediatr Child Health. 2003;  39 632-634
• 14 Siddiqui M A, McKenna B J. Hepatic mesenchymal hamartoma: a short review.  Arch Pathol Lab Med. 2006;  130 1567-1569