ABSTRACT
We present a case of successfully treated persistent bacteremia due to Gram-positive
bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses
(6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults
with no adverse events. Peak and trough serum concentrations of daptomycin were 22.9
and 11.6 μg/mL at day 4 as well as 27.3 and 7.9 μg/mL at day 11 after initiation of
treatment, respectively.
KEYWORDS
Daptomycin - neonate - drug monitoring - enterococcal bacteremia
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Emmanuel RoilidesM.D. Ph.D.
Associate Professor, 3rd Department of Pediatrics, Aristotle University
Hippokration General Hospital, Kostantinoupoleos 49, 54642, Thessaloniki, Greece
eMail: roilides@med.auth.gr
