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Synfacts 2010(9): 1004-1004  
DOI: 10.1055/s-0030-1257915
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Coumarin Dye as Selective Thiourea Sensor

Contributor(s): Timothy M. Swager, Shuang Liu
W. Lin*, X. Cao, L. Yuan, Y. Ding
Hunan University, Changsha, P. R. of China
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

The authors report a highly selective fluorescent turn-on sensor for thioureas. The fluorescence of the coumarin dye is fully quenched by both the carbonyl and bromide functional groups in compound 2, creating a dark sensing background. Intense turn-on response is observed only when both quenchers are removed by the reaction with the target analyte, as in the case of 3-5.