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Synfacts 2010(9): 0973-0973  
DOI: 10.1055/s-0030-1257935
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Englerins A and B

Contributor(s): Steven V. Ley, Kimberley A. Roper
K. Molawi, N. Delpont, A. M. Echavarren*
Institute of Chemical Research of Catalonia and Universitat Rovira i Virgilli, Tarragona, Spain
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

(-)-Englerins A and B are guaiane sesquiterpenes that are active against renal cancer cell growth. Englerin B is less active and selective than englerin A. This synthesis was published back-to-back with Ma and co-workers who also used a gold-catalyzed cycloisomerization (see previous Synfact). Overall, englerin A was synthesized in 18 steps in 7% yield.