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Synfacts 2010(9): 1023-1023  
DOI: 10.1055/s-0030-1257939
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Chiral Chelating Hydroxyalkyl NHC Ligands for Allylic Alkylation

Contributor(s): Hisashi Yamamoto, Patrick Brady
T. Jennequin, J. Wencel-Delord, D. Rix, J. Daubignard, C. Crévisy*, M. Mauduit*
Ecole Nationale Supérieure de Chimie de Rennes and Université Européenne de Bretagne, Rennes, France
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

The method described allows for efficient alkylation of allylic phosphates under mild conditions with high enantioselectivity. The substitution occurs with complete regioselectivity while requiring only 1 mol% of catalyst.