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Synfacts 2010(9): 1033-1033
DOI: 10.1055/s-0030-1257950
DOI: 10.1055/s-0030-1257950
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Synthesis of Heterocycles
S. Ogawa, N. Iida, E. Tokunaga, M. Shiro, N. Shibata*
Nagoya Institute of Technology and Rigaku Corporation, Akishima, Japan
Further Information
Publication History
Publication Date:
23 August 2010 (online)
Significance
Building upon previous work the authors report a cooperative catalyst system consisting of a cinchona alkaloid and Ti(Oi-Pr)4 for the enantioselective synthesis of heterocycles (N. Shibata, T. Toru and co-workers Synlett 2006, 3484). The heterocycles formed in this manner possess a quaternary center bearing a trifluoromethyl group. These novel heterocycles could be potentially interesting from a medicinal chemistry perspective.