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Synfacts 2010(9): 1078-1078
DOI: 10.1055/s-0030-1257975
DOI: 10.1055/s-0030-1257975
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Oxidation of Internal Alkynes with PdCl2/CuCl2 in PEG-H2O
S. Chandrasekhar*, N. K. Reddy, V. P. Kumar
Indian Institute of Chemical Technology, Hyderabad, India
Further Information
Publication History
Publication Date:
23 August 2010 (online)
Significance
PdCl2/CuCl2 promoted the oxidation of internal alkynes 1 in PEG-H2O to afford the corresponding 1,2-diketones 2 in up to 87% yield (9 examples, eq. 1). The oxidation of internal alkynes followed by the subsequent treatment with 1,2-diaminobenzene gave the corresponding quinoxalines 3 in up to 81% yield (4 examples, eq. 2).