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Synfacts 2010(10): 1137-1137
DOI: 10.1055/s-0030-1258640
DOI: 10.1055/s-0030-1258640
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New YorkBreak Symmetry, and Get Benefits
G. M. Fischer, C. Jüngst, M. Isomäki-Krondahl, D. Gauss, H. M. Möller, E. Daltrozzo, A. Zumbusch*
Universität Konstanz, Germany
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Publikationsverlauf
Publikationsdatum:
22. September 2010 (online)
Significance
Modular synthetic approach to asymmetric-structured near-infrared (NIR) fluorophores 1 is described. The key to the stepwise synthesis is a successful isolation of intermediate (Int-A) in the first condensation of diketopyrrolopyrrole (DPP). The validity of this method is also demonstrated by synthesis and internalization of the cell-penetrating, oligopeptide-conjugated fluorophore 2 in living cells.