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Synfacts 2010(11): 1323-1323
DOI: 10.1055/s-0030-1258822
DOI: 10.1055/s-0030-1258822
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New YorkBuchwald-Hartwig Reaction with Amphiphilic Resin-Supported Palladium
Y. Hirai, Y. Uozumi*
Institute for Molecular Science, Okazaki and KANEKA Corporation, Takasago, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Oktober 2010 (online)

Significance
The amphiphilic polystyrene-poly-(ethylene glycol) resin supported di(tert-butyl)-phosphine-palladium complex was prepared and found to promote the Buchwald-Hartwig reaction in water. Thus, the complex 1-Pd was prepared from ligand 1 and palladium according to the reported procedures (Y. Hirai, Y. Uozumi Chem. Commun. 2010, 46, 1103). The amination of PhBr (3) was carried out with HNPh2 (4) in the presence of 1-Pd to give triphenylamine (5a) in 92% yield.