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Synfacts 2011(1): 0056-0056  
DOI: 10.1055/s-0030-1258987
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Hydrophosphonylation of Trifluoromethyl Ketones

Contributor(s): Hisashi Yamamoto, Patrick Brady
X. Zhou, Q. Zhang, Y. Hui, W. Chen, J. Jiang, L. Lin, X. Liu, X. Feng*
Sichuan University, Chengdu and Lanzhou University, P. R. of China
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Publikationsverlauf

Publikationsdatum:
21. Dezember 2010 (online)

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Significance

A Lewis acid catalyzed asymmetric synthesis of α-hydroxy trifluoromethyl phosphonates bearing a quaternary chiral center is reported. The authors suggest that the products are likely to have interesting bioactivities.