Palladium-Catalyzed Packed-Bed Continuous-Flow C-N
Cross-Coupling

doi:10.1055/s-0030-1259414

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Synfacts 2011(3): 0321-0321
DOI: 10.1055/s-0030-1259414

Metal-Mediated Synthesis

Palladium-Catalyzed Packed-Bed Continuous-Flow C-N Cross-Coupling

Contributor(s): Paul Knochel, Andreas J. Wagner
J. R. Naber, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA

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Publikationsverlauf

Publikationsdatum:
16. Februar 2011 (online)

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Significance

Conditions have been developed for the palladium-catalyzed C-N cross-coupling in a continuous-flow fashion, using microreactors packed with stainless steel spheres (packed-bed reactors). The reaction proceeds in a biphasic reaction medium (KOH-toluene) in the presence of palladium-phosphine catalyst systems and tetra-butylammonium bromide as a phase-transfer catalyst.