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Synfacts 2011(3): 0319-0319
DOI: 10.1055/s-0030-1259422
DOI: 10.1055/s-0030-1259422
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New YorkNickel-Catalyzed Reductive Cleavage of Aryl Ethers
P. Álvarez-Bercedo, R. Martín*
Institute of Chemical Research of Catalonia, Terragona, Spain
Further Information
Publication History
Publication Date:
16 February 2011 (online)
Significance
A catalytic reductive cleavage of inert C-O bonds of aryl methyl ethers as removable directing groups is described. The method uses Ni(cod)2 in catalytic amounts and is achieved without using halogenated or tin-based precursors.