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Synfacts 2011(3): 0316-0316
DOI: 10.1055/s-0030-1259424
DOI: 10.1055/s-0030-1259424
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Iron-Catalyzed Oxidative Addition of Alkoxycarbonyl Radicals
T. Taniguchi*, Y. Sugiura, H. Zaimoku, H. Ishibashi
Kanazawa University, Japan
Further Information
Publication History
Publication Date:
16 February 2011 (online)
Significance
This work discloses an iron-catalyzed intermolecular oxidative addition of alkoxycarbonyl radicals to alkenes. The radicals are generated from readily available carbazate precursors and the reaction is catalyzed by a low-toxic and inexpensive iron catalyst. The reaction proceeds in air and tolerates a range of functionalities, such as ester, bromo, and nitro substituents.