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Synfacts 2011(4): 0399-0399  
DOI: 10.1055/s-0030-1259650
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium(II)-Catalyzed Enantioselective C-H Functionalization of Indoles

Contributor(s): Mark Lautens, Norman Nicolaus
A. DeAngelis, V. W. Shurtleff, O. Dmitrenko, J. M. Fox*
University of Delaware, USA
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Publication History

Publication Date:
18 March 2011 (online)

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Significance

The indole scaffold is an important substructure in numerous biologically active natural products and pharmaceutically relevant targets. In particular, transition-metal-catalyzed direct functionalizations using reactive carbene intermediates are powerful strategies to achieve a selective modification of indoles. Herein, a rhodium-catalyzed and enantioselective C-H functionalization of indoles of type 1 by diazo compounds is described.