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Synfacts 2011(7): 0705-0705  
DOI: 10.1055/s-0030-1260487
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Viriditoxin

Contributor(s): Steven V. Ley, Philippa B. Cranwell
Y. S. Park, C. I. Grove, M. González-López, S. Urgaonkar, J. C. Fettinger, J. T. Shaw*
University of California, Davis, USA
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Publikationsdatum:
17. Juni 2011 (online)

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Erratum zu diesem Artikel:

Synthesis of (-)-ViriditoxinSynfacts 2011; 2011(09): 1037-1037
DOI: 10.1055/s-0030-1261045

Significance

(-)-Viriditoxin was originally isolated from the mold Aspergillus viridinutans and is a potent inhibitor of filamenting temperature-sensitive mutant Z (FtsZ), a protein involved in cell division. The absolute configuration at C3 had been determined, but the axial configuration was unknown.