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Synfacts 2011(7): 0796-0796  
DOI: 10.1055/s-0030-1260597
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of β-Amino Carbonyls with a Biomaterial-Supported Organocatalyst

Contributor(s): Yasuhiro Uozumi, Fumie Sakurai
S. Verma, S. L. Jain*, B. Sain*
Indian Institute of Petroleum, Dehradun, India
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Publication History

Publication Date:
17 June 2011 (online)

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Significance

Biomaterial-supported organocatalyst 1 was synthesized by mixing expanded corn starch and chlorosulfonic acid followed by treatment with pyridine (eq. 1). Catalyst 1 promoted the aza-Michael addition of amines 2 to electron-deficient alkenes 3 to give the corresponding β-amino carbonyls 4 in up to 96% yield (27 examples, eq. 2).