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Synfacts 2011(9): 1000-1000  
DOI: 10.1055/s-0030-1260887
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Access to Benzyl Boronates via Suzuki Coupling of Diborylmethane

Contributor(s): Paul Knochel, Andreas J. Wagner
K. Endo*, T. Ohkubo, T. Shibata*
Waseda Institute for Advanced Study, Tokyo, PRESTO, Japan Science and Technology Agency, Saitama and Waseda University, Tokyo, Japan
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Publication History

Publication Date:
19 August 2011 (online)

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Significance

The authors report a chemoselective Pd-catalyzed Suzuki-Miyaura coupling of a range of substituted aryl bromides with methy­lene-bis(pinacolato)boron. Various benzyl boronate derivatives are accessible by this method. Notably, also highly bulky substituents on the aryl bromide can be present.