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Synfacts 2011(10): 1113-1113  
DOI: 10.1055/s-0030-1261068
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed One-Pot Process to Yield 8-Arylquinolines

Contributor(s): Paul Knochel, Andreas K. Steib
Y. Zhang*, J. Gao, W. Li, H. Lee, B. Z. Lu, C. H. Senanayake
Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, USA
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

A palladium-catalyzed one-pot reaction to furnish 8-arylquinolines has been disclosed. 8-Quinoline halides are borylated via Pd-catalyzed reaction with bis(pinacolato)diboron and subsequently cross-coupled with aryl halides to yield the heteroaromatic products in good to excellent yields.