Synfacts 2011(10): 1086-1086  
DOI: 10.1055/s-0030-1261114
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Asymmetric Double Crotylation of 1,3-Diols

Contributor(s): Mark Lautens, Hasnain A. Malik
X. Gao, H. Han, M. J. Krische*
University of Texas at Austin, USA
Further Information

Publication History

Publication Date:
20 September 2011 (online)

Significance

Stereoselectivity in polyketide synthesis is usually achieved via stepwise carbonyl addition reactions. These strategies revolve around chiral auxiliaries, chiral catalysts/reagents, and premetalated nucleophiles. The authors present an elegant and powerful strategy (using alcohols as precursors to aldehydes) that helps advance the field.