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Synfacts 2012; 8(3): 0309
DOI: 10.1055/s-0031-1290218
DOI: 10.1055/s-0031-1290218
Metal-Mediated Synthesis
Tandem One-Pot Synthesis of Polysubstituted Pyridines
Further Information
Publication History
Publication Date:
20 February 2012 (online)
Significance
An efficient tandem one-pot process has been developed for the synthesis of polysubstituted pyridines with complete control of substitution patterns. The tandem reaction proceeds via the regio- and chemoselective addition of the Blaise reaction intermediate to the 1,3-enyne followed by an isomerization–cyclization–aromatization process.
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Comment
This convenient and straightforward process is characterized by high yields and its good functional group tolerance. The method described is very versatile due to various substitution patterns of the pyridine ring that can be generated.
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