Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators

Abstract

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1–21) or tetrahydrothiophene-1,1-dioxide ring (22–42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.

Key words

1,4-Dihydropyridine - thienopyridine - cyclopentapyridine - calcium channel modulator

• References

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