Synlett 2013; 24(6): 737-740
DOI: 10.1055/s-0032-1318347
letter
© Georg Thieme Verlag Stuttgart · New York

CuBr2-Promoted Tetrahydrofuranylation of Alcohols and 1,3-Dione

Meng-Ke Wang
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China   Fax: +86(577)86689300   Email: dengchenliang78@tom.com
,
Zeng-le Zhou
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China   Fax: +86(577)86689300   Email: dengchenliang78@tom.com
,
Ri-Yuan Tang
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China   Fax: +86(577)86689300   Email: dengchenliang78@tom.com
,
Xing-Guo Zhang
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China   Fax: +86(577)86689300   Email: dengchenliang78@tom.com
,
Chen-liang Deng*
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China   Fax: +86(577)86689300   Email: dengchenliang78@tom.com
› Author Affiliations
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Publication History

Received: 07 January 2013

Accepted after revision: 11 February 2013

Publication Date:
06 March 2013 (online)


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Abstract

A method for the CuBr2-promoted tetrahydrofuranylation of alcohols and 1,3-dione has been developed. A variety of different alcohols were efficiently converted into the corresponding 2-tetrahydrofuran ethers in the presence of CuBr2. It is noteworthy that this protocol also successfully converted 1,3-diphenyl-1,3-dione into the corresponding 2-tetrahydrofuran derivative in good yield.

Supporting Information