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Synfacts 2013; 9(4): 0393
DOI: 10.1055/s-0032-1318401
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Chiral Cyclopentadiene Ligands for the Asymmetric Allylation of Benzamides

Rezensent(en):
Mark Lautens
,
Harald Weinstabl
Ye B, Cramer N * École Polytechnique Fédérale de Lausanne, Switzerland
A Tunable Class of Chiral Cp Ligands for Enantioselective Rhodium(III)-Catalyzed C-H Allylations of Benzamides.

J. Am. Chem. Soc. 2013;
135: 636-639
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Publikationsdatum:
15. März 2013 (online)

 
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Key words

cyclopentadiene - C–H allylation - rhodium(III) - benzamides

Significance

A class of chiral Cp ligands with tuneable steric parameters is reported and used in the Rh(III)-catalyzed allylation of N-methoxybenz­amides. The obtained yields are good and the enantioselectivities excellent.


 

Comment

Cyclopentadienyl (Cp) ligands are among the most versatile and frequently used ligands to access robust and highly catalytically active transition-metal complexes. However, there are only a few chiral Cp ligands reported so far.


 

 


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