McDonald SL, Hendrick CE, Wang Q * Duke University, Durham, USA
Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C–H Zincation.
Angew. Chem. Int. Ed. 2014;
53: 4667-4670
Key words
copper - amination - zinc
Significance
Wang and co-workers describe a direct amination of (hetero)arenes by C–H zincation
followed by copper-catalyzed electrophilic amination using O-acyl hydroxylamines. A broad substrate scope, good functional-group tolerance, and
mild reaction conditions were demonstrated.
Comment
The C–H zincation was achieved applying either Zn(tmp)2 or tmpZnCl·LiCl (tmp = 2,2,6,6-tetramethylpiperidyl) at room temperature. The obtained
products were isolated in good to excellent yields.
