Artemisinin: A Case Study in the Evolution of Synthetic Strategy

Silas P. Cook

doi:10.1055/s-0033-1340627

Synlett, Table of Contents

Synlett 2014; 25(6): 751-759
DOI: 10.1055/s-0033-1340627

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Artemisinin: A Case Study in the Evolution of Synthetic Strategy

Silas P. Cook*

Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA Fax: +1(812)8558300 Email: sicook@indiana.edu

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Abstract

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Abstract

Artemisinin represents one of the most important discoveries in the fight against malaria over the last 50 years. As the first endoperoxide-containing natural product, artemisinin has attracted chemists and biologists alike with its potent activity and rapid onset against malaria-causing Plasmodium species. Since its disclosure in 1979, artemisinin has been the subject of several elegant syntheses. Herein, the evolution of synthetic strategy is discussed in the context of artemisinin.

Key words

terpenoids - total synthesis - malaria - natural products - endoperoxide

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References

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