Evaluation of Serum Lipid Profile in Patients with Hypertension Living in a Coastal Region of Bangladesh

Abstract

Serum lipid levels are greatly controlled by genetic and environmental factors. When investigating the relationship between lipid disturbances and hypertension it is necessary to use local data on blood lipid profile in each region. Unfortunately, there is no literature reporting the lipid profile in hypertensive patients in coastal region of Bangladesh. The present study was conducted as a case-control study with 100 hypertensive patients as cases and equal number of normotensive individuals as controls. Socio-demographic, anthropometric and clinical data of both patients and controls were collected. Serum lipid parameters were analyzed biochemically. Independent sample t-test, Chi-Square test and Pearson’s correlation test were done for the statistical analysis using the statistical software package SPSS. Our study found that serum total cholesterol (TC), triglyceride (TG), LDL, VLDL, TC/HDL, LDL/HDL were significantly higher (p<0.05) whereas the level of HDL cholesterol was significantly lower in hypertensive patients as compared to control subjects (p<0.05). Pearson’s correlation analysis reveals that HDL cholesterol was inversely correlated with systolic and diastolic blood pressure in both patient and control groups. But serum TC, TG, LDL and HDL cholesterol were directly correlated with systolic and diastolic blood pressure in both groups. This study explored that hypertensive patients have higher level of TC, TG, LDL and VLDL cholesterol but lower level of HDL cholesterol than the normotensive subjects. Routine investigation of lipid profile in hypertensive patients may help to prevent further aggravation and risks of coronary artery diseases.

Key words

hypertension - lipid profile - total cholesterol - triglyceride - HDL cholesterol - LDL cholesterol

• References

• 1 Akuyam SA, Aghogho UB, Aliyu IS et al. Serum total cholesterol in hypertensive Northern Nigerians. Int J Med and Med Sci 2009; 1: 73-78
• 2 World Health Organization (WHO) . International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee J Hypertens 1999; 17: 151-183
• 3 Al-Jarky F, Al-Awadhi N, Al-Fadli H et al. Prevalence of hypertension in young and middle aged Kuwaiti citizens in primary health care. Kuwait Med J 2005; 37: 116-119
• 4 Bansal SK, Saxena V, Kandpal SD et al. The prevalence of hypertension and hypertension risk factors in a rural Indian community: A prospective door-to-door study. J Cardiovasc Dis Res 2012; 3: 117-123
• 5 Saha MS, Sana NK, Shaha RK. Serum lipid profile of hypertensive patients in the northern region of Bangladesh. J Bio Sci 2006; 14: 93-98
• 6 Williams GH, Braunwald E. Hypertensive vascular disease. In: Harrison’s Principles of Internal Medicine. Prentice Hall 1987;
• 7 Hammoudeh AJ, Izraiq M, Al-Mousa E et al. Serum lipid profiles with and without CAD: Jordan hyperlipidemia and related targets study (JoHARTS). East Mediterr Health J 2008; 14: 24-32
• 8 Hemalatha J, Wilma DSCR. Evaluation of effect of smoking and hypertension on serum lipid profile and oxidative stress. Asian-Pac J Trop Dis 2011; 1: 289-291
• 9 Harvey JM, Beevers DG. Biochemical investigation of hypertension. Annals Clin Biochem 1990; 27: 287-296
• 10 Low PS, Saha N, Tay TS. Ethnic variation of cord plasma apolipoprotein levels in relation to coronary risk level: a study in three ethnic groups of Singapore. Acta Paeditr 1996; 85: 1476-1482
• 11 Ferreira SRJ, Iunes M, Franco LJ et al. Disturbances of glucose and lipid metabolism in first and second generation Japanese-Brazilians. Diabetes Res Clin Pract 1996; 34: 59-63
• 12 Ibrahim MM, Ibrahim A, Shaheen K et al. Lipid profile in Egyptian patients with coronary artery disease. Egypt Heart J 2013; 65: 79-85
• 13 Yusuf S, Hawken S, Ounpuu S et al. Effects of potentially modifiable risk factors associated with myocardial infarction in 52 countries (The Interheart Study): case-control study. Lancet 2004; 364: 937-942
• 14 Chobanian AV, Bakris GL, Black HR et al. Seventh report of the joint national committee on prevention, detection, Evaluation and treatment of high blood pressure. Hypertension 2003; 42: 1206-1252
• 15 Khandakar MR, Ahsan R, Haque MJ. Socio-economic status and risk of coronary heart disease (CHD) in a northern urban community of Bangladesh. Dinajpur Med Col J 2010; 3: 67-75
• 16 Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502
• 17 Glueck CJ, Segal P. Ratios and risk coronary heart disease. JAMA 1986; 255: 955-957
• 18 Jaffe M. Uber den niederschlag, welchen pikrinsaure in normalen hrn erzeugt und uber eine neue reaction des kreatinins. Z Physiol Chem 1886; 10: 391-400
• 19 Lawrence GD. Oxidation and lipid peroxidation. Fats of life: Essential Fatty Acids in Health and Disease. New Jersey USA 2010; 50-93
• 20 Halperin RO, Sesso HD, Ma J et al. Dyslipidemia and the risk of incident hypertension in men. Hypertension 2006; 47: 45-50
• 21 Borghi C. Interactions between hypercholesterolemia and hypertension: implications for therapy. Curr Opin Nephrol Hypertens 2002; 11: 489-496
• 22 Bamrara P, Mittal Y, Mathur A. Evaluation of lipid profile of North Indian hypertensive subjects. Asian J Biomed Pharm Sci 2013; 3: 1-3
• 23 Gormat NB, Benmansourb F, Hammas A. Lipid profile in type 2 diabetic and hypertensive population in Western Algeria. Annals Biol Res 2011; 2: 447-454
• 24 Yildiran H, Acar TN, Koksal E et al. The association of anthropometric measurements and lipid profiles in Turkish hypertensive adults. Afr Health Sci 2011; 11: 407-413
• 25 Akintunde AA. Epidemiology of conventional cardiovascular risk factors among hypertensive subjects with normal and impaired fasting glucose. South African Med J 2010; 100: 594-597
• 26 Lepira FB, M’Buyamba-Kabangu JR, Kayembe KP et al. Correlates of serum lipids and lipoproteine in Congolese patients with arterial hypertension. Cardiovasc J South Afr 2005; 16: 249-255
• 27 Albucher JF, Ferrieres J, Ruidavets JB et al. Serum lipids in young patients with ischaemic stroke: a case-control study. J Neurol Neurosur Ps 2000; 69: 29-33
• 28 Niyomtham S, Maneemaroj R, Chaisomboon C et al. Abdominal obesity, hypertension, hyperglycemia and dyslipidemia in rural Thai people. Asia J Public Health 2012; 3: 3-8
• 29 Osuji CU, Omejua GE, Onwubuya EI et al. Serum lipid profile of newly diagnosed hypertensive patients in Nnewi, South-East Nigeria. Int J Hypertens 2012; Article ID 710486
• 30 Asaolu MF, Asaolu SS, Fakunle JB et al. Evaluation of lipid status of hypertensive Nigerians in Ado-Ekiti, western Nigeria. Der Pharmacia Lettre 2010; 2: 6-9
• 31 McBride PE. Triglycerides and risk for coronary heart disease. JAMA 2007; 298: 336-338
• 32 Malhotra P, Kumari S, Singh S et al. Isolated lipid abnormalities in rural and urban normotensive and hypertensive North-West Indians. JAPI 2003; 51: 459-463
• 33 Kumar NL, Deepthi J, Rao YN et al. Study of lipid profile, serum magnesium and blood glucose in hypertension. Biol Med 2010; 2: 6-16
• 34 Pavithran P, Nandeesha H Madanmohan et al. Dyslipidemia antedates occurrence of clinical hypertension in non-diabetic, non-obese male subjects. Indian J Physiol Pharmacol 2007; 51: 96-98
• 35 Barter PJ, Nicholls S, Rye KA et al. Antiinflammatory properties of HDL. Circ Res 2004; 95: 764-772
• 36 Mackness MI, Durrington PN, Mackness B. How high-density lipoprotein protects against the effects of lipid peroxidation. Curr Opin Lipidol 2000; 11: 383-388
• 37 Gordon DJ, Probstfield JL, Garrison RJ. High density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 1989; 79: 8-15
• 38 Wali U, Binji AA, Ahmad K et al. Lipid peroxidation and lipid profile in hypertensive patients in Sokoto, Nigeria. Niger J Basic Appl Sci 2012; 20: 199-204
• 39 Peela J, Abdulla MJ. Lipid profile in essential hypertension. EJ BMB 2009; 35: 521-529
• 40 Murray KR, Doryl KG, Michael BG. Cardiovascular disorder pathogenesis and pathophysiology. Mostoy, USA 1993; 1-8
• 41 Kumar V, Pamzi SC, Stonley LR. Hypertension. Basic Pathology. New Delhi, India: Elsevier; 2004
• 42 Tavasoli AA, Sadegi M, Pourmoghaddas M et al. Lipid profile in uncomplicated non diabetic hypertensives. Iranian Heart J 2005; 6: 64-69
• 43 Kimm H, Lee SW, Lee HS et al. Associations between lipid measures and metabolic syndrome, insulin resistance and adiponectin. Usefulness of lipid ratios in Korean men and women. Circ J 2010; 74: 931-937
• 44 Kawamoto R, Tabara Y, Kohara K et al. Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults. Lipids Health Dis 2011; 10: 79
• 45 Sumner AE, Finley KB, Genovese DJ et al. Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans. Arch Intern Med 2005; 165: 1395-1400
• 46 Hoffman RP. Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents. Diabetes Care 2006; 29: 1402-1404
• 47 Rieler RJ. Oxidative processes and antioxidant defence mechanism in aging brain. Fed Am Soc Exper Biol 1995; 9: 526-533