Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

Abstract

Background: The aim of this study was to evaluate the reproducibility of the posterior pole asymmetry analysis (PPAA) in glaucomatous eyes and healthy controls in comparison to retinal nerve fiber layer measurements (RNFL) with spectral domain optical coherence tomography (SD-OCT).

Patients and Methods: Prospectively, in a single session by one operator, three measurements were taken of the retinal thickness with the PPAA and three measurements of the RNFL with the eye-tracker function of the Heidelberg Spectralis SD-OCT.

Results: The mean intraclass correlation coefficient (ICC) and lower confidence intervals (in parentheses) for PPAA were 0.98 (0.96) in both healthy (36 eyes) and glaucomatous eyes (26 eyes). Global coefficients of variation (COVs) were between 0.0 and 1.1 % in healthy controls and between 0.0 and 1.9 % in glaucoma eyes. Global ICCs for RNFL were 0.98 (0.96) in healthy controls and 0.98 (0.97) in glaucoma eyes and global COVs were between 0.0 and 6.8 % in healthy controls and between 0.0 and 3.0 % in glaucoma eyes.

Conclusion: Reproducibility of the PPAA was good and exceeds that of established RNFL measurements. Thus, PPAA is an additional useful tool in management of glaucoma.

Zusammenfassung

Hintergrund: Ziel war, die Reproduzierbarkeit der Posterior-Pole-Asymmetrie-Analyse (PPAA) in glaukomatösen und gesunden Augen im Vergleich zur peripapillären Nervenfaserschichtdickenmessung (RNFL) mit dem OCT zu evaluieren.

Patienten und Methoden: Prospektiv erfolgten in einer Sitzung von einem Untersucher 3 Messungen der Netzhautdicke von der PPAA und 3 Messungen von der RNFL unter Verwendung der Eye-Tracker-Funktion mit dem Heidelberg Spectralis SD-OCT.

Ergebnisse: Die Intraklassenkorrelation (ICC) betrug für die PPAA sowohl bei den gesunden (36 Augen) als auch bei den glaukomatösen Augen (26 Augen) 0,98 (0,96 Konfidenzintervall). Der Variationskoeffizient (COV) war bei gesunden Augen zwischen 0,0 und 1,1 %, bei glaukomatösen Augen zwischen 0,0 und 1,9 %. Die ICC für die RNFL betrug 0,98 (0,96) in gesunden Augen und 0,98 (0,97) in glaukomatösen Augen, der COV bewegte sich zwischen 0,0 und 6,8 % in gesunden und zwischen 0,0 und 3,0 % in glaukomatösen Augen.

Schlussfolgerungen: Die Reproduzierbarkeit mit der PPAA ist außerordentlich hoch und übertrifft sogar die der etablierten RNFL-Messung. Die PPAA ist ein zusätzliches, hilfreiches Instrument im Glaukommanagement.

Key words

optical coherence tomography - spectral-domain optical coherence tomography - SD-OCT - spectralis OCT - OCT - reproducibility - glaucoma - posterior pole asymmetry analysis

Schlüsselwörter

optische Kohärenztomografie - Spectral-Domain optische Kohärenztomografie - SD-OCT - Spectralis-OCT - OCT - Reproduzierbarkeit - Glaukom - Posterior-Pole-Asymmetrie-Analyse

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