Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir

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Synfacts 2014; 10(7): 0664
DOI: 10.1055/s-0034-1378233

Synthesis of Natural Products and Potential Drugs

Contributor(s):

Philip Kocienski

Further Information

Publication Date:
16 June 2014 (online)

PSI-6130 - sofosbuvir - HCV NS5B protease inhibitors - enantioselective α-oxyamination - Mukaiyama aldol reaction - pentoses - organocatalysis