Proline-Catalyzed Dehydrogenative Cross-Coupling Reaction between Chromene and Aldehydes

Abstract

An unprecedented DCC reaction between chromene and aldehydes catalyzed by proline has been developed via direct C–H functionalization. A plausible mechanism using DDQ to activate α-C–H of chromene and proline to activate aldehyde is also proposed.

Key words

C–H functionalization - DCC reaction - organocatalysis - oxidation - chromene

• References and Notes


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Ethers were oxidized by DDQ to form oxocarbenium ions. For details, see:
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