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Drug Res (Stuttg) 2015; 65(06): 300-305
DOI: 10.1055/s-0034-1384561
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Comparative Study of Three Traditional Mongolian Medicines on Streptozotocin-induced Diabetic Nephropathy in Rats

X.-L. Wang
1   Inner Mongolia National University of Mongolia Medical College, Tong liao, Inner Mongolia, P.R. China
,
A. Liji
1   Inner Mongolia National University of Mongolia Medical College, Tong liao, Inner Mongolia, P.R. China
,
J. Liu
2   Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, P.R. China
,
X.-Z. Wang
2   Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, P.R. China
,
C.-X. Wei
2   Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, P.R. China
› Author Affiliations
Further Information

Publication History

received 26 April 2014

accepted 16 May 2014

Publication Date:
22 July 2014 (online)

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Abstract

3 kinds of prescription of Traditional Mongolian (Chinese) Medicine (TMM) have been used in treating diabetic nephropathy (DN). We aimed to investigate: first, which prescription was more effective; second, whether it was more effective when combined with the 3 prescriptions. The DN model was prepared by a single dose of Streptozotocin (STZ, 65 mg/kg, i.p.) in rats and treated 3 times every day with P-1 (Sugmul-10), P-2 (Narenmandul-11), P-3 (Xieriga-4) respectively, and combined group was treated with P-1 in the morning, P-2 and P-3 in the evening. The results showed combining with 3 prescriptions in one day was much more effective than each single prescription. The mechanism of renal protection maybe related to MMP-2 and TGF-β1, the conclusion could be useful and beneficial for clinical medicine.

Key words

Sugmul-10 - Narenmandul-11 - Xieriga-4 - diabetic nephropathy - renal function

 

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