Drug Res (Stuttg) 2015; 65(07): 361-365
DOI: 10.1055/s-0034-1384577
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Ingenines A and B, Two New Alkaloids from the Indonesian Sponge Acanthostrongylophora ingens

S. R. M. Ibrahim
1   Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia
2   Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
,
G. A. Mohamed
3   Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
4   Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt
,
M. F. Zayed
1   Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia
5   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
,
H. M. Sayed
2   Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
› Author Affiliations
Further Information

Publication History

received 25 April 2014

accepted 30 June 2014

Publication Date:
22 July 2014 (online)

Abstract

As a continuation of the work on EtOAc fraction of the Indonesian sponge Acanthostrongylophora ingens, 2 new alkaloids: one pyrimidine-β-carboline alkaloid named ingenine A (2) and one pyrimidine-γ-carboline alkaloid named ingenine B (3), along with annomontine (1) were isolated. Their structures were unambiguously established on the basis of NMR spectroscopy (1 H, 13C, 1 H-1 H COSY, HMQC, and HMBC) and mass spectral data. This is the first report of isolation pyrimidine-γ-carboline alkaloid from natural source. Compounds 1 and 3 showed pronounced cytotoxicity against the murine lymphoma L5178Y cancer cell line with ED50 7.8 and 9.1 μg/mL respectively, while compound 2 showed weak activity.

 
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