Fortschr Neurol Psychiatr 2015; 83(05): 259-268
DOI: 10.1055/s-0034-1399413
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Neuropsychologische Behandlung kognitiver Defizite bei Suchtmittel-, affektiven, Angst- und Zwangserkrankungen – Aktueller Stand und Perspektiven

Neuropsychological Treatment of Cognitive Deficits in Substance Abuse Disorders, Affective Disorders, Anxiety Disorders and Obsessive-Compulsive Disorders – Current Status and Perspectives
V. C. Buschert
1   Neuropsychologie, Inn-Salzach-Klinikum, Wasserburg am Inn
,
P. Zwanzger
2   Psychiatrie, Inn-Salzach-Klinikum, Wasserburg am Inn
,
A. Brunnauer
1   Neuropsychologie, Inn-Salzach-Klinikum, Wasserburg am Inn
› Author Affiliations
Further Information

Publication History

09 January 2015

24 March 2015

Publication Date:
27 May 2015 (online)

Zusammenfassung

Neuropsychologische Behandlung ist ein vielversprechender Ansatz zur Verbesserung kognitiver Defizite bei neuropsychiatrischen Erkrankungen, die als Kernsymptom auch in Remissionsphasen fortbestehen können und einen wesentlichen Einfluss auf die psychosoziale Funktionsfähigkeit haben. Allerdings variieren Forschungsinteresse und Wirksamkeitsnachweise neuropsychologischer Behandlungsmaßnahmen zwischen den Krankheitsgruppen stark. Obwohl kognitive Behandlungsverfahren häufig im klinischen Alltag eingesetzt werden, gibt es, mit Ausnahme der Schizophrenie, relativ wenige Untersuchungen bezüglich ihrer Wirksamkeit.

Abstract

Neuropsychological treatment represents a promising therapeutic approach in the amelioration of cognitive deficits in many neuropsychiatric disorders. Cognitive impairment constitutes a core feature that often persists beyond psychopathological symptoms having a significant impact on psychosocial functioning. However, research interest and evidence of efficacy vary considerably between disease groups. Although neuropsychological treatment is frequently used in clinical practice, there are, with the exception of schizophrenia, relatively few studies on its effectiveness.

 
  • Referenzen

  • 1 Keshavan MS, Vinogradov S, Rumsey J et al. Cognitive training in mental disorders: update and future directions. Am J Psychiatry 2014; 171: 510-522
  • 2 Bates ME, Bowden SC, Barry D. Neurocognitive impairment associated with alcohol use disorders: implications for treatment. Exp Clin Psychopharmacol 2002; 10: 193-212
  • 3 McCleery A, Ventura J, Kern RS et al. Cognitive functioning in first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) Profile of Impairment. Schizophr Res 2014; 157: 33-39
  • 4 Martinez-Aran A, Vieta E, Reinares M et al. Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. Am J Psychiatry 2004; 161: 262-270
  • 5 Xu G, Lin K, Rao D et al. Neuropsychological performance in bipolar I, bipolar II and unipolar depression patients: a longitudinal, naturalistic study. J Affect Disord 2012; 136: 328-339
  • 6 Rock PL, Roiser JP, Riedel WJ et al. Cognitive impairment in depression: a systematic review and meta-analysis. Psychol Med 2013; 1-12
  • 7 Eysenck MW, Derakshan N, Santos R et al. Anxiety and cognitive performance: attentional control theory. Emotion 2007; 7: 336-353
  • 8 Greisberg S, McKay D. Neuropsychology of obsessive-compulsive disorder: a review and treatment implications. Clin Psychol Rev 2003; 23: 95-117
  • 9 Olley A, Malhi G, Sachdev P. Memory and executive functioning in obsessive-compulsive disorder: a selective review. J Affect Disord 2007; 104: 15-23
  • 10 Scheurich A, Lautenbacher S. Die klinische Neuropsychologie ist in die Psychiatrie zurückgekehrt. Neurologie & Psychiatrie 2008; 10: 41-45
  • 11 Green MF, Harvey PD. Cognition in schizophrenia: Past, present, and future. Schizophr Res Cogn 2014; 1: e1-e9
  • 12 Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998; 12: 426-445
  • 13 Vinogradov S, Fisher M, de Villers-Sidani E. Cognitive training for impaired neural systems in neuropsychiatric illness. Neuropsychopharmacology 2012; 37: 43-76
  • 14 Lam RW, Michalak EE, Bond DJ et al. Which depressive symptoms and medication side effects are perceived by patients as interfering most with occupational functioning?. Depress Res Treat 2012; 2012: 630206
  • 15 Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia?. Am J Psychiatry 1996; 153: 321-330
  • 16 Green MF, Kern RS, Heaton RK. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res 2004; 72: 41-51
  • 17 Withall A, Harris LM, Cumming SR. The relationship between cognitive function and clinical and functional outcomes in major depressive disorder. Psychol Med 2009; 39: 393-402
  • 18 Mukherjee S. Alcoholism and its effects on the central nervous system. Curr Neurovasc Res 2013; 10: 256-262
  • 19 Reppermund S, Ising M, Lucae S et al. Cognitive impairment in unipolar depression is persistent and non-specific: further evidence for the final common pathway disorder hypothesis. Psychol Med 2009; 39: 603-614
  • 20 Stavro K, Pelletier J, Potvin S. Widespread and sustained cognitive deficits in alcoholism: a meta-analysis. Addict Biol 2013; 18: 203-213
  • 21 Simons CJ, Jacobs N, Derom C et al. Cognition as predictor of current and follow-up depressive symptoms in the general population. Acta Psychiatr Scand 2009; 120: 45-52
  • 22 Bartok E, Berecz R, Glaub T et al. Cognitive functions in prepsychotic patients. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29: 621-625
  • 23 Weiss E, Singewald EM, Ruepp B et al. Alcohol induced cognitive deficits. Wien Med Wochenschr 2014; 164: 9-14
  • 24 Osler M, Lawlor DA, Nordentoft M. Cognitive function in childhood and early adulthood and hospital admission for schizophrenia and bipolar disorders in Danish men born in 1953. Schizophr Res 2007; 92: 132-141
  • 25 Trivedi MH, Greer TL. Cognitive dysfunction in unipolar depression: implications for treatment. J Affect Disord 2014; 152-154: 19-27
  • 26 Parslow RA, Jorm AF. Pretrauma and posttrauma neurocognitive functioning and PTSD symptoms in a community sample of young adults. Am J Psychiatry 2007; 164: 509-515
  • 27 Volz HP, Reischies F, Riedel M. Cognitive disorders in schizophrenic patients. Nervenarzt 2010; 81: 39-54
  • 28 Mannie ZN, Barnes J, Bristow GC et al. Memory impairment in young women at increased risk of depression: influence of cortisol and 5-HTT genotype. Psychol Med 2009; 39: 757-762
  • 29 Bora E, Yucel M, Pantelis C. Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord 2009; 113: 1-20
  • 30 Mishara AL, Goldberg TE. A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book. Biol Psychiatry 2004; 55: 1013-1022
  • 31 McIntyre RS, Cha DS, Soczynska JK et al. Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depress Anxiety 2013; 30: 515-527
  • 32 Kurtz MM. Cognitive remediation for schizophrenia: current status, biological correlates and predictors of response. Expert Rev Neurother 2012; 12: 813-821
  • 33 Wykes T, Newton E, Landau S et al. Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial. Schizophr Res 2007; 94: 221-230
  • 34 Dilling H. Internationale Klassifikation psychischer Störungen. ICD-10 Kapitel V (F); Forschungskriterien. Bern: Huber; 1994
  • 35 Falkai P, Wittchen HU. Diagnostisches und Statistisches Manual Psychischer Störungen DSM-5®. Hogrefe 2015
  • 36 Jacobi F, Hofler M, Strehle J et al. Mental disorders in the general population: Study on the health of adults in Germany and the additional module mental health (DEGS1-MH). Nervenarzt 2014; 85: 77-87
  • 37 Boake C. History of cognitive rehabilitation following head injury. In: Kreutzner JS, Wehman PH, Hrsg Cognitive rehabilitation for persons with traumatic brain injury. Baltimore: Brooks; 1991
  • 38 Parente R, Stapleton M. History and systems of cognitive rehabilitation. NeuroRehabilitation 1997; 8: 3-11
  • 39 Ben-Yishay Y, Diller L. Cognitive remediation in traumatic brain injury: update and issues. Arch Phys Med Rehabil 1993; 74: 204-213
  • 40 McGurk SR, Twamley EW, Sitzer DI et al. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry 2007; 164: 1791-1802
  • 41 Wykes T, Huddy V, Cellard C et al. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry 2011; 168: 472-485
  • 42 Weisbrod M, Aschenbrenner S, Pfuller U et al. Rehabilitation in persons with schizophrenic spectrum disorders: the impact of cognition and cognitive remediation therapy. Fortschr Neurol Psychiatr 2014; 82: 128-134
  • 43 Vauth R, Dietl M, Stieglitz RD et al. Cognitive remediation. A new chance in rehabilitation of schizophrenic disorders?. Nervenarzt 2000; 71: 19-29
  • 44 Gauggel S. Grundlagen und Empirie der Neuropsychologischen Therapie: Neuropsychotherapie oder Hirnjogging?. Zeitschrift für Neuropsychologie 2003; 14: 217-224
  • 45 Etkin A, Gyurak A, O'Hara R. A neurobiological approach to the cognitive deficits of psychiatric disorders. Dialogues Clin Neurosci 2013; 15: 419-429
  • 46 Fett AK, Viechtbauer W, Dominguez MD et al. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 2011; 35: 573-588
  • 47 Bowie CR, Gupta M, Holshausen K. Cognitive remediation therapy for mood disorders: rationale, early evidence, and future directions. Can J Psychiatry 2013; 58: 319-325
  • 48 Bechara A, Dolan S, Denburg N et al. Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia 2001; 39: 376-389
  • 49 Schmidt SJ, Mueller DR, Roder V. Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling. Schizophr Bull 2011; 37 (Suppl. 02) S41-S54
  • 50 Marker K. COGPACK. In: Marker Software: Ladenburg; 1999
  • 51 Finauer G. Therapiemanuale für die neuropsychologische Rehabilitation. (Hrsg) Heidelberg: Springer; 2007
  • 52 Roder V, Brenner HD, Kienzle N. Integriertes Psychologisches Therapieprogramm bei schizophren Erkrankten (IPT). 6. überarb. Aufl. Weinheim: Beltz PVU; 2008
  • 53 Exner C, Lincoln T. Neuropsychologie schizophrener Störungen. Göttingen, Bern Wien, Paris, Oxford, Prag, Toronto: Hogrefe; 2012
  • 54 Cellard C, Whaley S, Wykes T. Revisiting Cognitive Remediation for Schizophrenia: Facing the Challenges of the Future. In: Ritsner MS, Hrsg. Handbook of schizophrenia spectrum disorders. Springer; 2011
  • 55 Deckersbach T, Nierenberg AA, Kessler R et al. RESEARCH: Cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther 2010; 16: 298-307
  • 56 Bowie CR, McGurk SR, Mausbach B et al. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real-world behavior. Am J Psychiatry 2012; 169: 710-718
  • 57 Snyder HR. Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychol Bull 2013; 139: 81-132
  • 58 Lee RS, Hermens DF, Porter MA et al. A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder. J Affect Disord 2012; 140: 113-124
  • 59 Beard C, Sawyer AT, Hofmann SG. Efficacy of attention bias modification using threat and appetitive stimuli: a meta-analytic review. Behav Ther 2012; 43: 724-740
  • 60 Roiser JP, Sahakian BJ. Hot and cold cognition in depression. CNS Spectr 2013; 18: 139-149
  • 61 Martino DJ, Strejilevich SA, Scapola M et al. Heterogeneity in cognitive functioning among patients with bipolar disorder. J Affect Disord 2008; 109: 149-156
  • 62 Elgamal S, McKinnon MC, Ramakrishnan K et al. Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study. Psychol Med 2007; 37: 1229-1238
  • 63 Naismith SL, Diamond K, Carter PE et al. Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training program. Am J Geriatr Psychiatry 2011; 19: 240-248
  • 64 Bowie CR, Gupta M, Holshausen K et al. Cognitive remediation for treatment-resistant depression: effects on cognition and functioning and the role of online homework. J Nerv Ment Dis 2013; 201: 680-685
  • 65 Preiss M, Shatil E, Cermakova R et al. Personalized cognitive training in unipolar and bipolar disorder: a study of cognitive functioning. Front Hum Neurosci 2013; 7: 1-10
  • 66 Naismith SL, Redoblado-Hodge MA, Lewis SJ et al. Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approach. J Affect Disord 2010; 121: 258-262
  • 67 Anaya C, Martinez AranA, Ayuso-Mateos JL et al. A systematic review of cognitive remediation for schizo-affective and affective disorders. J Affect Disord 2012; 142: 13-21
  • 68 Lee RS, Redoblado-Hodge MA, Naismith SL et al. Cognitive remediation improves memory and psychosocial functioning in first-episode psychiatric out-patients. Psychol Med 2013; 43: 1161-1173
  • 69 Siegle G, Ghinassi F, Thase M. Neurobehavioral therapies in the 21st century: Summary of an emerging field and an extended example of cognitive control training for depression. Cognitive Therapy and Research 2007; 31: 235-262
  • 70 Siegle GJ, Steinhauer SR, Friedman ES et al. Remission prognosis for cognitive therapy for recurrent depression using the pupil: utility and neural correlates. Biol Psychiatry 2011; 69: 726-733
  • 71 Meusel LA, Hall GB, Fougere P et al. Neural correlates of cognitive remediation in patients with mood disorders. Psychiatry Res 2013; 214: 142-152
  • 72 Torrent C, Bonnin Cdel M, Martinez-Aran A et al. Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study. Am J Psychiatry 2013; 170: 852-859
  • 73 Wiedemann G, Klingberg S, Pitschel-Walz G. Psychoedukative Interventionen in der Behandlung von Patienten mit schizophrenen Störungen. Nervenarzt 2003; 74: 76-84
  • 74 Sanches M, Bauer IE, Galvez JF et al. The Management of Cognitive Impairment in Bipolar Disorder: Current Status and Perspectives. Am J Ther 2014;
  • 75 Harvey PD, Wingo AP, Burdick KE et al. Cognition and disability in bipolar disorder: lessons from schizophrenia research. Bipolar Disord 2010; 12: 364-375
  • 76 Bates ME, Buckman JF, Nguyen TT. A role for cognitive rehabilitation in increasing the effectiveness of treatment for alcohol use disorders. Neuropsychol Rev 2013; 23: 27-47
  • 77 Crean RD, Crane NA, Mason BJ. An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions. J Addict Med 2011; 5: 1-8
  • 78 Baldacchino A, Balfour DJ, Passetti F et al. Neuropsychological consequences of chronic opioid use: a quantitative review and meta-analysis. Neurosci Biobehav Rev 2012; 36: 2056-2068
  • 79 Wood S, Sage JR, Shuman T et al. Psychostimulants and cognition: a continuum of behavioral and cognitive activation. Pharmacol Rev 2013; 66: 193-221
  • 80 Uekermann J, Daum I, Schlebusch P et al. Processing of affective stimuli in alcoholism. Cortex 2005; 41: 189-194
  • 81 Wiers RW, Eberl C, Rinck M et al. Retraining automatic action tendencies changes alcoholic patients' approach bias for alcohol and improves treatment outcome. Psychol Sci 2011; 22: 490-497
  • 82 Rupp CI, Kemmler G, Kurz M et al. Cognitive remediation therapy during treatment for alcohol dependence. J Stud Alcohol Drugs 2012; 73: 625-634
  • 83 Schoenmakers TM, de Bruin M, Lux IF et al. Clinical effectiveness of attentional bias modification training in abstinent alcoholic patients. Drug Alcohol Depend 2010; 109: 30-36
  • 84 Gamito P, Oliveira J, Lopes P et al. Executive functioning in alcoholics following an mHealth cognitive stimulation program: randomized controlled trial. J Med Internet Res 2014; 16: e102
  • 85 Scheurich A, Brokate B. Neuropsychologie der Alkoholabhängigkeit. Göttingen Bern Wien Paris Oxford Prag Toronto: 2009
  • 86 Bickel WK, Yi R, Landes RD et al. Remember the future: working memory training decreases delay discounting among stimulant addicts. Biol Psychiatry 2011; 69: 260-265
  • 87 Brewin CR. The nature and significance of memory disturbance in posttraumatic stress disorder. Annu Rev Clin Psychol 2011; 7: 203-227
  • 88 Bar-Haim Y, Lamy D, Pergamin L et al. Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychol Bull 2007; 133: 1-24
  • 89 Chang CT, Chang YH, Yung-Wei WuJ et al. Neuropsychological functions impairment in different subtypes of bipolar disorder with or without comorbid anxiety disorders. Psychiatry Res 2012; 200: 246-251
  • 90 Brunnauer A, Laux G. Klinisch-Neuropsychologische Aspekte der Therapie mit Psychopharmaka. In: Lautenbacher S, Gauggel S, Hrsg. Neuropsychologie psychischer Störungen. Berlin, Heidelberg: Springer; 2010: 525-549
  • 91 MacLeod C, Mathews A, Tata P. Attentional bias in emotional disorders. Journal of Abnormal Psychology 1986; 95: 15-20
  • 92 Schmidt NB, Richey JA, Buckner JD et al. Attention training for generalized social anxiety disorder. J Abnorm Psychol 2009; 118: 5-14
  • 93 Amir N, Beard C, Taylor CT et al. Attention training in individuals with generalized social phobia: A randomized controlled trial. J Consult Clin Psychol 2009; 77: 961-973
  • 94 Amir N, Beard C, Burns M et al. Attention modification program in individuals with generalized anxiety disorder. J Abnorm Psychol 2009; 118: 28-33
  • 95 Hakamata Y, Lissek S, Bar-Haim Y et al. Attention bias modification treatment: a meta-analysis toward the establishment of novel treatment for anxiety. Biol Psychiatry 2011; 68: 982-990
  • 96 Henry JD. A meta-analytic review of Wisconsin Card Sorting Test and verbal fluency performance in obsessive-compulsive disorder. Cogn Neuropsychiatry 2006; 11: 156-176
  • 97 Deckersbach T, Otto MW, Savage CR et al. The relationship between semantic organization and memory in obsessive-compulsive disorder. Psychother Psychosom 2000; 69: 101-107
  • 98 Chamberlain SR, Blackwell AD, Fineberg NA et al. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 2005; 29: 399-419
  • 99 DGPPN. S3-Leitlinie Zwangsstörungen. In: Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN); 2013
  • 100 Buhlmann U, Deckersbach T, Engelhard I et al. Cognitive retraining for organizational impairment in obsessive-compulsive disorder. Psychiatry Res 2006; 144: 109-116
  • 101 Lautenbacher S, Kunz M. Neuropsychologie der Schizophrenie. In: Lautenbacher S, Gauggel S, Hrsg. Neuropsychologie psychischer Störungen. Berlin, Heidelberg: Springer; 2010: 331-346
  • 102 DGPPN. Behandlungsleitlinie Schizophrenie. In: S3 Praxisleitlinien in Psychiatrie und Psychotherapie. Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN); 2006
  • 103 Krabbendam L, Aleman A. Cognitive rehabilitation in schizophrenia: a quantitative analysis of controlled studies. Psychopharmacology (Berl) 2003; 169: 376-382
  • 104 Bossert M, Weisbrod M, Aschenbrenner S. Cognitive remediation in clinical routine: a study on psychiatric patients' acceptance. Fortschr Neurol Psychiatr 2014; 82: 691-694