The Biosynthesis and Biomimetic Synthesis of Merochlorins A and B

Abstract

The interplay between biosynthetic studies and biomimetic synthesis is discussed in the context of the merochlorin family of marine natural products. Total syntheses of merochlorin A by our group and merochlorin B by the Trauner group are presented alongside the biosynthetic studies of Moore and co-workers. The common theme is the generation of complex polycyclic ring systems by oxidative dearomatization–cyclization cascade reactions.

Key words

biomimetic synthesis - cascade reactions - natural products - meroterpenoids - oxidative dearomatization

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