The Development of Aza-Pinacol and Aza-Semipinacol Rearrangements for the Synthesis of Nitrogen-Containing Molecules

Abstract

Although the widespread usage of aza-pinacol and aza-semipinacol rearrangements as synthetic methods has not been found, these synthetic transformations offer novel tactics for the preparation of nitrogen-containing heterocycles and natural alkaloids. Herein, we briefly discuss the most recent developments in this area and present our strategy based on aza-pinacol rearrangements for the synthesis of indolines and indolenines.

1 Introduction

2 Recently Developed Aza-Pinacol and Aza-Semipinacol Rearrangements

3 Indoline/Indolenine Synthesis Employing Aza-Pinacol Rearrangements as the Key Strategy

4 Conclusion

Key words

indoline - indolenine - indoxyl - aza-pinacol rearrangement - aza-semipinacol rearrangement

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