Subscribe to RSS
Palladium Cross-Couplings with a Silicon-Based Transfer Agent
Design, Synthesis, and Validation of an Effective, Reusable Silicon-Base Transfer Agent for Room-Temperature Pd-Catalyzed Cross-Coupling Reactions of Aryl and Heteroaryl Chlorides with Readily Available Aryl Lithium Reagents.
J. Am. Chem. Soc. 2016;
15 March 2016 (online)
The authors present a reusable, bench-stable, silicon-based transfer agent for effective room-temperature palladium-catalyzed cross-couplings of aryl chlorides with aryl lithium reagents.
DFT calculations outline the importance of the CF3 groups of the transfer agent and support a σ-bond-metathesis mechanism during transmetalation.