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Am J Perinatol 2016; 33(07): 640-645
DOI: 10.1055/s-0036-1571319
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Insulin-Like Growth Factor-1 Levels in Term Newborns with Hypoxic–Ischemic Encephalopathy

Raid M. R. Umran
1   Department of Pediatrics, College of Medicine, University of Kufa, Al-Zahraa Teaching Hospital, Najaf Health Directorate, Najaf, Iraq
,
Mahir Al-Tahir
2   Najaf Health Directorate, Al-Zahraa Teaching Hospital, Najaf, Iraq
,
Desai Jagdish
3   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Hutzel Women Hospital, Detroit
,
Nitin Chouthai
3   Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Hutzel Women Hospital, Detroit
› Author Affiliations
Further Information

Publication History

16 July 2015

11 December 2015

Publication Date:
05 February 2016 (online)

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Abstract

Objective This study aims to evaluate the correlation of changes in serum insulin-like growth factor-1 (IGF-1) levels with the clinical staging of hypoxic–ischemic encephalopathy (HIE) in term newborns.

Study Design A prospective study of 29 newborns with HIE (stage I = 15, stage II + III = 14) and 28 healthy term newborns as the control group was performed in the neonatal intensive care unit. IGF-1 levels were obtained within 6 hours after birth from HIE and control groups and again on day 3 from HIE group. HIE was classified using the Sarnat staging I to III.

Results IGF-1 levels were significantly lower in the HIE group than in the control group (p = 0.024). It was lower in the HIE stage II to III group compared with HIE stage I group at birth (p < 0.0001) and on day 3 (p = 0.009). The mean IGF-1 levels were significantly higher on day 3 than on day 1 among stage II to III HIE (p = 0.006) and it was inversely correlated with staging (R =  − 0.475, p = 0.009). There was a significant correlation between IGF-1 levels and Apgar score at 5 (R = 0.39, p = 0.042) and 10 minutes (R = 0.38, p = 0.035).

Conclusions IGF-1 was lower in HIE and inversely correlated with clinical staging. It was increased with clinical improvement in the subsequent days.

Keywords

insulin-like growth factor-1 - IGF-1 - hypoxic–ischemic encephalopathy - HIE - birth asphyxia
 

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