Miller Fisher Syndrome Associated with Parvovirus B19 Infection in a Child

Abstract

Miller Fisher syndrome (MFS) is a variant of Guillain–Barré syndrome, and it is typically characterized by the triad of ophthalmoplegia, ataxia, and areflexia. We report a 13-year-old boy affected with MFS associated with parvovirus B19 infection in which immunoglobulin (Ig)G and IgM anti-GQ1b antibodies were not detected. Treatment with intravenous Igs resulted in a progressive and rapid resolution of the clinical features. To our knowledge, this is the first example in the literature of seronegative anti-GQ1b antibody MFS associated with parvovirus B19 infection in childhood. The possible role of other gangliosides is discussed.

Keywords

parvovirus B19 - Miller Fisher syndrome - childhood - immunoglobulins

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