Synthesis of Emindole SB

Abstract

Paxilline indole diterpenes have been a subject of scientific inquiry for over 30 years due to their diverse biological activities and unique structural features. These efforts resulted in a multitude of synthetic approaches and a dozen completed synthesis. Here, we discuss our contributions to this area that culminated in an 11-step synthesis of (±)-emindole SB.

Key words

natural products - synthesis - terpenoids - indoles - polycyclization - radical addition - stereoselectivity

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