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Aromatic Hydroxylation and Amination through Deprotonative Cupration
Direct Hydroxylation and Amination of Arenes via Deprotonative Cupration.
J. Am. Chem. Soc. 2016;
19 September 2016 (online)
The authors report an efficient aromatic hydroxylation and amination reaction through directed ortho cupration. The method is applicable to a wide range of functionalized aromatic and heteroaromatic compounds, and shows high chemo- and regioselectivity.
The reported reaction is the first example of an efficient, one-pot synthesis of functionalized phenols and anilines from the same substrates.