Synfacts 2016; 12(12): 1285
DOI: 10.1055/s-0036-1589685
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow

Paul Knochel
Marthe Ketels
Lima F, Kabeshov MA, Tran DN, Battilocchio C, Sedelmeier J, Sedelmeier G, Schenkel B, Ley SV * University of Cambridge, UK and Novartis Pharma AG, Switzerland
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow.

Angew. Chem. Int. Ed. 2016;
55: 14085-14089
Further Information

Publication History

Publication Date:
17 November 2016 (online)



The authors report an efficient and high-throughput continuous flow process employing a new method for the photoredox activation of boronic esters.



No additive other than the photoredox catalyst is required for the coupling of the hetero­aromatic nitriles and pinacol boronic esters because the nitrogen-containing heterocycle serves as the activator for the boronic ester.