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Synfacts 2016; 12(12): 1285
DOI: 10.1055/s-0036-1589685
DOI: 10.1055/s-0036-1589685
Metal-Mediated Synthesis
Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow
Authors
Lima F, Kabeshov MA, Tran DN, Battilocchio C, Sedelmeier J, Sedelmeier G, Schenkel B, Ley SV * University of Cambridge, UK and Novartis Pharma AG, Switzerland
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow.
Angew. Chem. Int. Ed. 2016;
55: 14085-14089
Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)–C(sp3) Cross-Couplings in Flow.
Angew. Chem. Int. Ed. 2016;
55: 14085-14089
Further Information
Publication History
Publication Date:
17 November 2016 (online)
Significance
The authors report an efficient and high-throughput continuous flow process employing a new method for the photoredox activation of boronic esters.
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Comment
No additive other than the photoredox catalyst is required for the coupling of the heteroaromatic nitriles and pinacol boronic esters because the nitrogen-containing heterocycle serves as the activator for the boronic ester.
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