Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2017; 13(01): 0043
DOI: 10.1055/s-0036-1589729
DOI: 10.1055/s-0036-1589729
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Palladium-Catalyzed Asymmetric Synthesis of α,α-Disubstituted Allylic N-Arylamines
Cai A, Guo W, * Martínez-Rodríguez L, Kleij AW. * The Barcelona Institute of Science and Technology and Catalan Institute of Research and Advanced Studies, Barcelona, Spain
Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons.
J. Am. Chem. Soc. 2016;
138: 14194-14197
Palladium-Catalyzed Regio- and Enantioselective Synthesis of Allylic Amines Featuring Tetrasubstituted Tertiary Carbons.
J. Am. Chem. Soc. 2016;
138: 14194-14197
Further Information
Publication History
Publication Date:
19 December 2016 (online)
![](https://www.thieme-connect.de/media/synfacts/201701/i_h161_s1_10-1055_s-0036-1589729.gif)
Significance
The synthesis of α,α-disubstituted allylic amines is quite challenging. The authors report a palladium-catalyzed regio- and enantioselective allylic amination of vinyl cyclic carbonates with nonactivated aromatic amines to give the corresponding α,α-disubstituted allylic N-arylamines in good to excellent yields and high enantioselectivities.
#
Comment
The method is very simple and uses readily available starting materials. The amine products can serve as chiral building blocks for natural products and biologically active molecules.
#
#
![](https://www.thieme-connect.de/media/synfacts/201701/i_h161_s1_10-1055_s-0036-1589729.gif)